Tissue Donation Indiana

Tissue for Research

Note: Tissue segments are postage stamp size.

Neonatal Tissue Donation

LIVER

Liver tissue and neonatal cells are the subject of a new method to treat hemophilia and metabolic liver
disease using cell transplants. The cells will also be used as a “liver assist device” to treat patients in liver
failure that are waiting for a transplant. The researchers believe cells obtained from neonates have
properties that make them ideal for transplants and in vitro proliferation.

KNEES

Chondrocytes from neonate knees have already shown promise in animal trials. The next generation of
clinical joint replacement therapy will utilize a combination of synthetic substrates (e.g., plastic)
impregnated with mammalian cells. The substrate will supply the shape, profile, and provide the weight
bearing properties. The chondrocytes will coat the surface of the substrate and provide the necessary
natural interface with reparative properties. If successful this approach will hopefully provide long-term
durability and less painful therapy for patients.

HEART

An exciting new advancement in cardiovascular disease is the treatment of heart failure and chronic
myocardial ischemia using stem cells. Myogenic cells are transplanted into injured myocardium to restore
lost heart muscle cells and improve ventricular function. Allograft stem cells from animal embryos and
fetuses have shown promise in pre-clinical trials. This therapy using allograft stem cells from human
neonate heart tissue is the subject of a cardiovascular institute study.

Criteria

Kidney Donor

Gestation age > 27 weeks at time of delivery

Live birth

Weight > 1000 gm

Survival age < 28 days from birth

Known cause of death

Exclude Trisomy 13, 18 and 21

No evidence of maternal high risk behavior

Warm ischemic time < 8 hours

Mandatory maternal and donor blood

Liver and Heart Donor Research

Age > 27 weeks at time of donation

Live Birth

Weight > 1000gms

Survival age to 42 days

Known cause of death

No evidence of maternal high risk behavior

Trisomy acceptable

Mandatory maternal blood only

Warm ischemic time: 8 hrs

Skin Tissue from hairline Donor Research (1cm2 biopsy punch)

Age > 27 weeks at time of donation

Live Birth

Weight > 1000gms

Survival age to 42 days

Known cause of death

No evidence of maternal high risk behavior

No Trisomy

Mandatory maternal blood only

Warm ischemic time: 8 hrs

Knee Donor for Cartilage Research

Age > 27 weeks at time of donation

Survival age to 10 years

Live Birth

Weight > 1000gm

Known cause of death

Warm ischemic time: 8 to 15 hours

Mandatory maternal blood if donor is < 3 months of age, donor blood if > 3 months

Trisomy acceptable

Excludes skeletal system diseases/conditions

Donor Diagnosis	Tissue Recovered
Metabolic Disorders (Diabetes) Diabetes Type I Diabetes Type II	Tissue segments from gallbladder, spleen, adiopose tissue from abdomen, pancreas and liver. Also, remove lymph node.
Osteoarthritis/Rheumatoid Arthritis Osteoarthritis Rheumatoid Arthritis	Dependent on most arthritic area. Tissue segments from the knee joint or toe joint. No hand joints.
Cardiovascular Disease Myocardial Infarction Congestive Heart Failure Cardiomyopathy Arteriosclerosis	Tissue segments from the heart, including pericardium.
Respiratory Diseases Asthma Emphysema Chronic Obstructive Pulmonary Disease (COPD) Pneumonia Adult Respiratory Distress Syndrome (ARDS) Cystic Fibrosis Pulmonary Fibrosis Lupus	Tissue segments from all 5 lobes of the lungs. This could be up to 20 tissue specimens.
Neurological Diseases Alzheimer’s Disease Schizophrenia Parkinson’s Disease Amyotrophic Lateral Sclerosis (ALS) Manic Depression Bipolar Disorder	Tissue segments from the brain. Do not need to remove whole brain unless that is what the family is requesting.

Colorectal Cancer	Tissue segments from colon and rectum. (Isolate tumor if possible)
Lymphoma	Lymph Nodes. Tissue segments from liver and spleen.
Prostate Cancer	Tissue segments from prostate.
Kidney Cancer (Renal Cell Carcinoma)	Tissue segments from kidney and bladder.
Breast Cancer	Tissue segments from both breasts.
Lung Cancer	Tissue segments form lungs, include tissue specimens from all 5 lobes.
Chronic Lymphocytic Leukemia	Lymph Nodes
Acute Lymphocytic Leukemia	Lymph Nodes
Malignant Myeloma	Lymph Nodes